So, generally, it's not recommended to mix the two.
In effect, what you are doing is mixing drugs, which can have unpredictable effects. When you drink the grapefruit juice (or eat the grapefruit), how much you drink or eat, what type it is, etc. can all play a factor. What else you've eaten, your weight, etc. can also have an effect. So there's just no way to predict how your body will react.
Now it appears that grapefruit juice can also affect the absorption of the popular erectile dysfunction drug Viagra (Sildenafil). Because erectile dysfunction is common in some males with HIV/AIDS, we report on the interaction between grapefruit juice and Viagra.
Researchers found that the absorption of Viagra increased by 23% when taken with grapefruit juice instead of water. Grapefruit juice also delayed the absorption of Viagra. This latter point is important because Viagra is supposed to be taken one hour before sex, and taking the drug with grapefruit juice may result in disappointment for some users of Viagra.
Grapefruit is an excellent source of vitamin C and other nutrients. However, for men taking ED medications, including Viagra (Sildenafil), consuming grapefruit-containing foods, juice and beverages is not advised. Grapefruit contains certain substances that can interfere with the metabolism of Viagra.
Therefore, drinking grapefruit juice while using Viagra is not a good idea. Even a single glass of grapefruit can significantly increase the risk of side effects. Studies show that one glass of grapefruit juice can substantially (up to 47%) reduce the amount of enzyme needed by the body to absorb and process Viagra.
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